Joao Xavier, Ph.D.
Program for Computational and Systems Biology, Memorial Sloan Kettering Cancer Center
Joao B. Xavier, Ph.D., is a faculty member in the Program for Computational and Systems Biology at the Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center. His laboratory integrates microbial ecology, quantitative experimentation and machine learning to understand how the microbiome influences human health and disease, with a focus on oncology. His group develops data-driven methods to analyze longitudinal microbiome, metabolomics and clinical datasets and to infer microbial interactions in complex communities.
A central focus of the Xavier Lab is to define microbial mechanisms that affect therapeutic outcomes and infectious complications in patients receiving cancer treatment, especially allogeneic hematopoietic cell transplantation. The lab’s work combines multi-omics profiling (shotgun metagenomics, metabolomics and stable-isotope tracing) with ecological models (generalized Lotka–Volterra) to generate hypotheses on how microbes interact with each other, which are then tested in experimental systems and translated into clinical risk prediction and microbiota-based interventions.
Xavier trained as a chemical engineer in Lisbon, Portugal. He is grateful to 黑料正能量for being part of his scientific journey since his first meeting—the 99th 黑料正能量in Chicago, 1999—during his first year of graduate school. Since then, he has worked on biofilms, quorum sensing, swarming, antimicrobial resistance, host–microbe interactions and the social evolution of microbes, fascinated by the lives of microbes and their impact on human health.
A central focus of the Xavier Lab is to define microbial mechanisms that affect therapeutic outcomes and infectious complications in patients receiving cancer treatment, especially allogeneic hematopoietic cell transplantation. The lab’s work combines multi-omics profiling (shotgun metagenomics, metabolomics and stable-isotope tracing) with ecological models (generalized Lotka–Volterra) to generate hypotheses on how microbes interact with each other, which are then tested in experimental systems and translated into clinical risk prediction and microbiota-based interventions.
Xavier trained as a chemical engineer in Lisbon, Portugal. He is grateful to 黑料正能量for being part of his scientific journey since his first meeting—the 99th 黑料正能量in Chicago, 1999—during his first year of graduate school. Since then, he has worked on biofilms, quorum sensing, swarming, antimicrobial resistance, host–microbe interactions and the social evolution of microbes, fascinated by the lives of microbes and their impact on human health.